{"metadata":{"accession":"PF19987","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046308","hierarchy":null,"name":{"name":"Family of unknown function (DUF6423)","short":"DUF6423"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001503) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the  amycolamycin A biosynthetic gene cluster from Amycolatopsis sp. [[cite:PUB00099467]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099467":{"PMID":29090939,"ISBN":null,"volume":"19","issue":"22","year":2017,"title":"Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.","URL":null,"raw_pages":"6208-6211","medline_journal":"Org Lett","ISO_journal":"Org Lett","authors":["Ma SY","Xiao YS","Zhang B","Shao FL","Guo ZK","Zhang JJ","Jiao RH","Sun Y","Xu Q","Tan RX","Ge HM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":68,"pathways":0,"proteins":68,"proteomes":68,"sets":0,"structural_models":{"alphafold":42},"structures":0,"taxa":120},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":25},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}