{"metadata":{"accession":"PF19985","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046306","hierarchy":null,"name":{"name":"Family of unknown function (DUF6421)","short":"DUF6421"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000877) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the polyoxin A biosynthetic gene cluster from Streptomyces cacaoi subsp. asoensis [[cite:PUB00098986]]. This family appears to be predominantly found in Actinobacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098986":{"PMID":19233844,"ISBN":null,"volume":"284","issue":"16","year":2009,"title":"Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.","URL":null,"raw_pages":"10627-38","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Chen W","Huang T","He X","Meng Q","You D","Bai L","Li J","Wu M","Li R","Xie Z","Zhou H","Zhou X","Tan H","Deng Z."],"DOI_URL":null},"PUB00098985":{"PMID":19383687,"ISBN":null,"volume":"155","issue":"Pt 6","year":2009,"title":"polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.","URL":null,"raw_pages":"1819-1831","medline_journal":"Microbiology (Reading)","ISO_journal":"Microbiology (Reading)","authors":["Li R","Xie Z","Tian Y","Yang H","Chen W","You D","Liu G","Deng Z","Tan H."],"DOI_URL":null}},"set_info":{"accession":"CL0126","name":"Peptidase_MA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1747,"pathways":0,"proteins":1746,"proteomes":1649,"sets":1,"structural_models":{"alphafold":857},"structures":7,"taxa":1944},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":849},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9j3g","name":"Fe2+/pterin-dependent, apo SmPolE"}}}