This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000299) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular the alterochromide A biosynthetic gene cluster from Pseudoalteromonas piscicida JCM 20779 [[cite:PUB00098870]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098870":{"PMID":25140825,"ISBN":null,"volume":"4","issue":"4","year":2015,"title":"Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform.","URL":null,"raw_pages":"414-20","medline_journal":"ACS Synth Biol","ISO_journal":"ACS Synth Biol","authors":["Ross AC","Gulland LE","Dorrestein PC","Moore BS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":26,"pathways":0,"proteins":26,"proteomes":25,"sets":0,"structural_models":{"alphafold":13},"structures":0,"taxa":36},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":6},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}