This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001589) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the exopolysaccharides biosynthetic gene cluster from Burkholderia cenocepacia J2315 [[cite:PUB00099462]]. This family appears to be predominantly found in Proteobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099462":{"PMID":28658258,"ISBN":null,"volume":"11","issue":"6","year":2017,"title":"Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster.","URL":null,"raw_pages":"e0005689","medline_journal":"PLoS Negl Trop Dis","ISO_journal":"PLoS Negl Trop Dis","authors":["Borlee GI","Plumley BA","Martin KH","Somprasong N","Mangalea MR","Islam MN","Burtnick MN","Brett PJ","Steinmetz I","AuCoin DP","Belisle JT","Crick DC","Schweizer HP","Borlee BR."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":88,"pathways":0,"proteins":88,"proteomes":86,"sets":0,"structural_models":{"alphafold":54},"structures":0,"taxa":204},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}