This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001514) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the aristeromycin biosynthetic gene cluster from Streptomyces citricolor [[cite:PUB00098880]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098880":{"PMID":27577857,"ISBN":null,"volume":"17","issue":"22","year":2016,"title":"Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin.","URL":null,"raw_pages":"2143-2148","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Kudo F","Tsunoda T","Takashima M","Eguchi T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1576,"pathways":0,"proteins":1576,"proteomes":1555,"sets":0,"structural_models":{"alphafold":798},"structures":0,"taxa":1779},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":126,"alignment:full":722},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}