{"metadata":{"accession":"PF19946","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045639","hierarchy":null,"name":{"name":"Family of unknown function (DUF6408)","short":"DUF6408"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000106) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the naphthomycin A biosynthetic gene cluster from Streptomyces sp. CS [[cite:PUB00098883]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098883":{"PMID":21614382,"ISBN":null,"volume":"7","issue":"8","year":2011,"title":"Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.","URL":null,"raw_pages":"2459-69","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Wu Y","Kang Q","Shen Y","Su W","Bai L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":64,"pathways":0,"proteins":64,"proteomes":63,"sets":0,"structural_models":{"alphafold":12},"structures":0,"taxa":86},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":16},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}