This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000464) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular the xenoamicin A biosynthetic gene cluster from Xenorhabdus doucetiae [[cite:PUB00098890]]. This family appears to be predominantly found in proteobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098890":{"PMID":24203528,"ISBN":null,"volume":"19","issue":"49","year":2013,"title":"Structure and biosynthesis of xenoamicins from entomopathogenic Xenorhabdus.","URL":null,"raw_pages":"16772-9","medline_journal":"Chemistry","ISO_journal":"Chemistry","authors":["Zhou Q","Grundmann F","Kaiser M","Schiell M","Gaudriault S","Batzer A","Kurz M","Bode HB."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":343,"pathways":0,"proteins":330,"proteomes":217,"sets":0,"structural_models":{"alphafold":181},"structures":0,"taxa":475},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":109},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}