This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001580) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the ebelactone biosynthetic gene cluster from Kitasatospora aburaviensis [[cite:PUB00098891]]. This family appears to be predominantly found in actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098891":{"PMID":27829923,"ISBN":null,"volume":"12","issue":null,"year":2016,"title":"Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase.","URL":null,"raw_pages":"2164-2172","medline_journal":"Beilstein J Org Chem","ISO_journal":"Beilstein J Org Chem","authors":["Hong H","Sun Y","Zhou Y","Stephens E","Samborskyy M","Leadlay PF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":826,"pathways":0,"proteins":826,"proteomes":678,"sets":0,"structural_models":{"alphafold":480},"structures":0,"taxa":804},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":57,"alignment:full":376},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}