This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000967) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the calyculin A biosynthetic gene cluster from uncultured Candidatus Entotheonella sp. [[cite:PUB00098893]]. This family appears to be predominantly found in proteobacteria and cyanobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098893":{"PMID":24974231,"ISBN":null,"volume":"10","issue":"8","year":2014,"title":"Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.","URL":null,"raw_pages":"648-55","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Wakimoto T","Egami Y","Nakashima Y","Wakimoto Y","Mori T","Awakawa T","Ito T","Kenmoku H","Asakawa Y","Piel J","Abe I."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":79,"pathways":0,"proteins":79,"proteomes":38,"sets":0,"structural_models":{"alphafold":63},"structures":0,"taxa":130},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":54},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}