{"metadata":{"accession":"PF19925","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045662","hierarchy":null,"name":{"name":"Family of unknown function (DUF6388)","short":"DUF6388"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001859) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular fosfomycin biosynthetic gene cluster from Pseudomonas syringae [[cite:PUB00098902],[cite:PUB00143563]]. This family is predominantly found in proteobacteria. Some members of this family have been putatively identified as DNA repair proteins.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098902":{"PMID":22615277,"ISBN":null,"volume":"56","issue":"8","year":2012,"title":"Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.","URL":null,"raw_pages":"4175-83","medline_journal":"Antimicrob Agents Chemother","ISO_journal":"Antimicrob Agents Chemother","authors":["Kim SY","Ju KS","Metcalf WW","Evans BS","Kuzuyama T","van der Donk WA."],"DOI_URL":null},"PUB00143563":{"PMID":3759643,"ISBN":null,"volume":"39","issue":"7","year":1986,"title":"Production of fosfomycin (phosphonomycin) by Pseudomonas syringae.","URL":null,"raw_pages":"1011-2","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Shoji J","Kato T","Hinoo H","Hattori T","Hirooka K","Matsumoto K","Tanimoto T","Kondo E."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":597,"pathways":0,"proteins":597,"proteomes":390,"sets":0,"structural_models":{"alphafold":270},"structures":0,"taxa":439},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":66},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}