This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001055) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the yersiniabactin biosynthetic gene cluster from Escherichia coli [[cite:PUB00098903]]. This family appears to be predominantly found in proteobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098903":{"PMID":17049458,"ISBN":null,"volume":"296","issue":"8","year":2006,"title":"Specific regions of genome plasticity and genetic diversity of the commensal Escherichia coli A0 34/86.","URL":null,"raw_pages":"541-6","medline_journal":"Int J Med Microbiol","ISO_journal":"Int J Med Microbiol","authors":["Hejnova J","Pages D","Rusniok C","Glaser P","Sebo P","Buchrieser C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":274,"pathways":0,"proteins":273,"proteomes":240,"sets":0,"structural_models":{"alphafold":146},"structures":0,"taxa":458},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":85},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}