This presumed domain is functionally uncharacterised. This domain is mainly found at the C-terminal of uncharacterised proteins, predominantly from Bacteriodetes. It is about 74 amino acids in length and it contains the GQ and GxxV/IV conserved sequence motifs. This domain has similarity to the Type IX secretion system targeting domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":241,"pathways":0,"proteins":241,"proteomes":55,"sets":1,"structural_models":{"alphafold":101},"structures":0,"taxa":123},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":166},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}