{"metadata":{"accession":"PF19894","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045947","hierarchy":null,"name":{"name":"Family of unknown function (DUF6367)","short":"DUF6367"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001053) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the tubulysin A biosynthetic gene cluster from Archangium disciforme [[cite:PUB00099437]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099437":{"PMID":15324808,"ISBN":null,"volume":"11","issue":"8","year":2004,"title":"Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.","URL":null,"raw_pages":"1071-9","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Sandmann A","Sasse F","Muller R."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":33,"pathways":0,"proteins":33,"proteomes":32,"sets":0,"structural_models":{"alphafold":20},"structures":0,"taxa":121},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":11},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}