{"metadata":{"accession":"PF19892","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045945","hierarchy":null,"name":{"name":"Family of unknown function (DUF6365)","short":"DUF6365"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001960) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the hiroshidine biosynthetic gene cluster from Streptomyces hiroshimensis [[cite:PUB00099455]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099455":{"PMID":30830740,"ISBN":null,"volume":"14","issue":"4","year":2019,"title":"Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria.","URL":null,"raw_pages":"767-774","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Moon K","Xu F","Zhang C","Seyedsayamdost MR."],"DOI_URL":null}},"set_info":{"accession":"CL0113","name":"GT-B"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":84,"pathways":0,"proteins":81,"proteomes":57,"sets":1,"structural_models":{"alphafold":48},"structures":0,"taxa":146},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":20,"alignment:full":45},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}