This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001807) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the totopotensamide A biosynthetic gene cluster from Streptomyces pactum [[cite:PUB00099468]]. This family appears to be predominantly present in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099468":{"PMID":29019409,"ISBN":null,"volume":"19","issue":"20","year":2017,"title":"Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides.","URL":null,"raw_pages":"5697-5700","medline_journal":"Org Lett","ISO_journal":"Org Lett","authors":["Chen R","Zhang Q","Tan B","Zheng L","Li H","Zhu Y","Zhang C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":429,"pathways":0,"proteins":429,"proteomes":312,"sets":0,"structural_models":{"alphafold":180},"structures":0,"taxa":420},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":158},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}