{"metadata":{"accession":"PF19871","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045925","hierarchy":null,"name":{"name":"Family of unknown function (DUF6344)","short":"DUF6344"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000843) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the alanylclavam biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064 [[cite:PUB00099389],[cite:PUB00099390]]. This family appears to be predominantly found in Actinobacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099389":{"PMID":22435762,"ISBN":null,"volume":"58","issue":"4","year":2012,"title":"A comparison of the clavam biosynthetic gene clusters in  Streptomyces antibioticus  Tu1718 and  Streptomyces clavuligerus.","URL":null,"raw_pages":"413-25","medline_journal":"Can J Microbiol","ISO_journal":"Can J Microbiol","authors":["Goomeshi Nobary S","Jensen SE."],"DOI_URL":null},"PUB00099390":{"PMID":15644894,"ISBN":null,"volume":"50","issue":"10","year":2004,"title":"Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus.","URL":null,"raw_pages":"803-10","medline_journal":"Can J Microbiol","ISO_journal":"Can J Microbiol","authors":["Tahlan K","Park HU","Jensen SE."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":597,"pathways":0,"proteins":597,"proteomes":592,"sets":0,"structural_models":{"alphafold":249},"structures":0,"taxa":635},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":285},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}