This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001877) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311 [[cite:PUB00099474]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099474":{"PMID":30705269,"ISBN":null,"volume":"10","issue":"1","year":2019,"title":"The antimicrobial potential of Streptomyces from insect microbiomes.","URL":null,"raw_pages":"516","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Chevrette MG","Carlson CM","Ortega HE","Thomas C","Ananiev GE","Barns KJ","Book AJ","Cagnazzo J","Carlos C","Flanigan W","Grubbs KJ","Horn HA","Hoffmann FM","Klassen JL","Knack JJ","Lewin GR","McDonald BR","Muller L","Melo WGP","Pinto-Tomas AA","Schmitz A","Wendt-Pienkowski E","Wildman S","Zhao M","Zhang F","Bugni TS","Andes DR","Pupo MT","Currie CR."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":47,"pathways":0,"proteins":47,"proteomes":42,"sets":0,"structural_models":{"alphafold":22},"structures":0,"taxa":78},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}