This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001593) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular the ficellomycin biosynthetic gene cluster from Streptomyces ficellus [[cite:PUB00099388]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099388":{"PMID":28894917,"ISBN":null,"volume":"101","issue":"20","year":2017,"title":"Identification and characterization of the ficellomycin biosynthesis gene cluster from Streptomyces ficellus.","URL":null,"raw_pages":"7589-7602","medline_journal":"Appl Microbiol Biotechnol","ISO_journal":"Appl Microbiol Biotechnol","authors":["Liu Y","Li M","Mu H","Song S","Zhang Y","Chen K","He X","Wang H","Dai Y","Lu F","Yan Z","Zhang H."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":81,"pathways":0,"proteins":81,"proteomes":71,"sets":0,"structural_models":{"alphafold":26},"structures":0,"taxa":99},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":21},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}