This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000274) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the tetarimycin A biosynthetic gene cluster from uncultured bacterium [[cite:PUB00099401]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099401":{"PMID":23157252,"ISBN":null,"volume":"134","issue":"48","year":2012,"title":"Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.","URL":null,"raw_pages":"19552-5","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Kallifidas D","Kang HS","Brady SF."],"DOI_URL":null}},"set_info":{"accession":"CL0942","name":"Beta-camber"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":114,"pathways":0,"proteins":113,"proteomes":82,"sets":1,"structural_models":{"alphafold":42},"structures":0,"taxa":110},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":46},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}