This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001598) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the foxicins A-D biosynthetic gene cluster from Streptomyces diastatochromogenes [[cite:PUB00099472]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099472":{"PMID":28270798,"ISBN":null,"volume":"8","issue":null,"year":2017,"title":"Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties.","URL":null,"raw_pages":"221","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Greule A","Marolt M","Deubel D","Peintner I","Zhang S","Jessen-Trefzer C","De Ford C","Burschel S","Li SM","Friedrich T","Merfort I","Ludeke S","Bisel P","Muller M","Paululat T","Bechthold A."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":536,"pathways":0,"proteins":536,"proteomes":520,"sets":0,"structural_models":{"alphafold":216},"structures":0,"taxa":563},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":261},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}