This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000219) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in particular the elloramycin biosynthetic gene cluster from Streptomyces olivaceus [[cite:PUB00099394]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099394":{"PMID":18310024,"ISBN":null,"volume":"154","issue":"Pt 3","year":2008,"title":"Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.","URL":null,"raw_pages":"781-788","medline_journal":"Microbiology (Reading)","ISO_journal":"Microbiology (Reading)","authors":["Ramos A","Lombo F","Brana AF","Rohr J","Mendez C","Salas JA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":3275,"pathways":0,"proteins":3243,"proteomes":2748,"sets":0,"structural_models":{"alphafold":1732},"structures":0,"taxa":3369},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":376,"alignment:full":1525},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}