This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001520) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the aurantinin B biosynthetic gene cluster from Bacillus subtilis [[cite:PUB00098962]]. This family appears to be predominantly present in Firmicutes.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098962":{"PMID":27806569,"ISBN":null,"volume":"64","issue":"46","year":2016,"title":"Genomics-Inspired Discovery of Three Antibacterial Active Metabolites, Aurantinins B, C, and D from Compost-Associated Bacillus subtilis fmb60.","URL":null,"raw_pages":"8811-8820","medline_journal":"J Agric Food Chem","ISO_journal":"J Agric Food Chem","authors":["Yang J","Zhu X","Cao M","Wang C","Zhang C","Lu Z","Lu F."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":342,"pathways":0,"proteins":342,"proteomes":331,"sets":0,"structural_models":{"alphafold":234},"structures":0,"taxa":601},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":98,"alignment:full":242},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}