This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001740) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the phthoxazolin biosynthetic gene cluster from Streptomyces avermitilis [[cite:PUB00098835]]. Shows some similarity to secretion system proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098835":{"PMID":29324854,"ISBN":null,"volume":"13","issue":"1","year":2018,"title":"Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.","URL":null,"raw_pages":"e0190973","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Suroto DA","Kitani S","Arai M","Ikeda H","Nihira T."],"DOI_URL":null}},"set_info":{"accession":"CL0352","name":"EsxAB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":540,"pathways":0,"proteins":540,"proteomes":413,"sets":1,"structural_models":{"alphafold":253},"structures":0,"taxa":548},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":247},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}