{"metadata":{"accession":"PF19822","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046271","hierarchy":null,"name":{"name":"Family of unknown function (DUF6304)","short":"DUF6304"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000262) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in  particular the prejadomycin biosynthetic gene cluster from  Streptomyces sp. PGA64 [[cite:PUB00099417],[cite:PUB00099451]]. This family appears to be  predominantly found in bacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099451":{"PMID":17654627,"ISBN":null,"volume":"8","issue":"13","year":2007,"title":"Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways.","URL":null,"raw_pages":"1577-84","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Palmu K","Ishida K","Mantsala P","Hertweck C","Metsa-Ketela M."],"DOI_URL":null},"PUB00099417":{"PMID":15515887,"ISBN":null,"volume":"57","issue":"8","year":2004,"title":"Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.","URL":null,"raw_pages":"502-10","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Metsa-Ketela M","Ylihonko K","Mantsala P."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":253,"pathways":0,"proteins":250,"proteomes":248,"sets":0,"structural_models":{"alphafold":116},"structures":0,"taxa":398},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":133},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}