This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002024) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular, the nargenicin biosynthetic gene cluster from Nocardia argentinensis [[cite:PUB00099422]]. This family appears to be predominantly found in bacteria and unclassified phages.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099422":{"PMID":30867595,"ISBN":null,"volume":"568","issue":"7750","year":2019,"title":"Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.","URL":null,"raw_pages":"122-126","medline_journal":"Nature","ISO_journal":"Nature","authors":["Zhang B","Wang KB","Wang W","Wang X","Liu F","Zhu J","Shi J","Li LY","Han H","Xu K","Qiao HY","Zhang X","Jiao RH","Houk KN","Liang Y","Tan RX","Ge HM."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":160,"pathways":0,"proteins":160,"proteomes":147,"sets":0,"structural_models":{"alphafold":80},"structures":0,"taxa":222},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":69},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}