This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000376) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23 [[cite:PUB00099434]]. This family appears to be predominantly found in actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099434":{"PMID":25041948,"ISBN":null,"volume":"21","issue":"8","year":2014,"title":"Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23.","URL":null,"raw_pages":"923-34","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Muliandi A","Katsuyama Y","Sone K","Izumikawa M","Moriya T","Hashimoto J","Kozone I","Takagi M","Shin-ya K","Ohnishi Y."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":499,"pathways":0,"proteins":494,"proteomes":481,"sets":1,"structural_models":{"alphafold":209},"structures":0,"taxa":556},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":233},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}