This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001922) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the isoindolinomycin biosynthetic gene cluster from Streptomyces sp. SoC090715LN-16 [[cite:PUB00098935]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098935":{"PMID":30080389,"ISBN":null,"volume":"13","issue":"9","year":2018,"title":"Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster.","URL":null,"raw_pages":"2615-2622","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Thong WL","Shin-Ya K","Nishiyama M","Kuzuyama T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":350,"pathways":0,"proteins":350,"proteomes":348,"sets":0,"structural_models":{"alphafold":211},"structures":0,"taxa":522},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":166},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}