This BGC (BGC0000081) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650CC [[cite:PUB00098878]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098878":{"PMID":23360970,"ISBN":null,"volume":"9","issue":"3","year":2013,"title":"Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.","URL":null,"raw_pages":"478-91","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Lohman JR","Huang SX","Horsman GP","Dilfer PE","Huang T","Chen Y","Wendt-Pienkowski E","Shen B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":102,"pathways":0,"proteins":102,"proteomes":96,"sets":0,"structural_models":{"alphafold":61},"structures":0,"taxa":186},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":43},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}