This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001203) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the clarexpoxcin biosynthetic gene cluster from uncultured bacterium AR_456 [[cite:PUB00099430]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099430":{"PMID":25831524,"ISBN":null,"volume":"112","issue":"14","year":2015,"title":"Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.","URL":null,"raw_pages":"4221-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Owen JG","Charlop-Powers Z","Smith AG","Ternei MA","Calle PY","Reddy BV","Montiel D","Brady SF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":973,"pathways":0,"proteins":973,"proteomes":464,"sets":0,"structural_models":{"alphafold":583},"structures":0,"taxa":604},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":129,"alignment:full":382},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}