{"metadata":{"accession":"PF19801","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046251","hierarchy":null,"name":{"name":"Family of unknown function (DUF6284)","short":"DUF6284"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis [[cite:PUB00098957]]. This family appears to be predominantly found in  Actinoabactteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098957":{"PMID":19362651,"ISBN":null,"volume":"459","issue":null,"year":2009,"title":"Enzymology of aminoglycoside biosynthesis-deduction from gene clusters.","URL":null,"raw_pages":"459-91","medline_journal":"Methods Enzymol","ISO_journal":"Methods Enzymol","authors":["Wehmeier UF","Piepersberg W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":733,"pathways":0,"proteins":733,"proteomes":502,"sets":0,"structural_models":{"alphafold":350},"structures":0,"taxa":615},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":62,"alignment:full":343},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}