This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001590) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the formicamycins A-M biosynthetic gene cluster from Streptomyces sp. KY5 [[cite:PUB00098929]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098929":{"PMID":28507698,"ISBN":null,"volume":"8","issue":"4","year":2017,"title":"Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants.","URL":null,"raw_pages":"3218-3227","medline_journal":"Chem Sci","ISO_journal":"Chem Sci","authors":["Qin Z","Munnoch JT","Devine R","Holmes NA","Seipke RF","Wilkinson KA","Wilkinson B","Hutchings MI."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":833,"pathways":0,"proteins":833,"proteomes":820,"sets":0,"structural_models":{"alphafold":359},"structures":0,"taxa":922},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":57,"alignment:full":392},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}