This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001096) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the FR901464 biosynthetic gene cluster from Pseudomonas sp. 2663 [[cite:PUB00099400]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099400":{"PMID":21291275,"ISBN":null,"volume":"133","issue":"8","year":2011,"title":"Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units.","URL":null,"raw_pages":"2452-62","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Zhang F","He HY","Tang MC","Tang YM","Zhou Q","Tang GL."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":35,"pathways":0,"proteins":35,"proteomes":33,"sets":0,"structural_models":{"alphafold":26},"structures":0,"taxa":77},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":13},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}