This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000119) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in particular the 7-deoxypactamycin biosynthetic gene cluster from Streptomyces pactum [[cite:PUB00099419],[cite:PUB00099449],[cite:PUB00099466]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099449":{"PMID":19670201,"ISBN":null,"volume":"10","issue":"13","year":2009,"title":"Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.","URL":null,"raw_pages":"2253-65","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Ito T","Roongsawang N","Shirasaka N","Lu W","Flatt PM","Kasanah N","Miranda C","Mahmud T."],"DOI_URL":null},"PUB00099466":{"PMID":23521145,"ISBN":null,"volume":"15","issue":"7","year":2013,"title":"Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity.","URL":null,"raw_pages":"1678-81","medline_journal":"Org Lett","ISO_journal":"Org Lett","authors":["Almabruk KH","Lu W","Li Y","Abugreen M","Kelly JX","Mahmud T."],"DOI_URL":null},"PUB00099419":{"PMID":17827660,"ISBN":null,"volume":"60","issue":"8","year":2007,"title":"Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.","URL":null,"raw_pages":"492-503","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Kudo F","Kasama Y","Hirayama T","Eguchi T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":603,"pathways":0,"proteins":603,"proteomes":600,"sets":0,"structural_models":{"alphafold":244},"structures":0,"taxa":659},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":61,"alignment:full":270},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}