This domain is predominantly found in Firmicute bacterial proteins and is functionally uncharacterised. It is found in proteins that are likely to be surface exposed. It is predicted to fold into a globular structure with C-type lectin topology. This domain is frequently found in combination with other carbohydrate-binding domains implying that it may be involved in carbohydrate recognition/binding.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0056","name":"C_Lectin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":110,"interactions":0,"matches":734,"pathways":0,"proteins":704,"proteomes":436,"sets":1,"structural_models":{"alphafold":403},"structures":1,"taxa":892},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":22,"alignment:full":562},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}