{"metadata":{"accession":"PF19787","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046238","hierarchy":null,"name":{"name":"Family of unknown function (DUF6271)","short":"DUF6271"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000093) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis [[cite:PUB00099370],[cite:PUB00099380]]. This family appears to be predominantly found in bacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099370":{"PMID":12811466,"ISBN":null,"volume":"180","issue":"2","year":2003,"title":"Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.","URL":null,"raw_pages":"101-7","medline_journal":"Arch Microbiol","ISO_journal":"Arch Microbiol","authors":["Sun Y","Zhou X","Tu G","Deng Z."],"DOI_URL":null},"PUB00099380":{"PMID":20348291,"ISBN":null,"volume":"76","issue":"10","year":2010,"title":"Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.","URL":null,"raw_pages":"3283-92","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["He Y","Sun Y","Liu T","Zhou X","Bai L","Deng Z."],"DOI_URL":null}},"set_info":{"accession":"CL0110","name":"GT-A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":374,"pathways":0,"proteins":362,"proteomes":338,"sets":1,"structural_models":{"alphafold":165},"structures":0,"taxa":466},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":181},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}