This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000974) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the crocacin biosynthetic gene cluster from Chondromyces crocatus [[cite:PUB00099439]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099439":{"PMID":24981773,"ISBN":null,"volume":"21","issue":"7","year":2014,"title":"Biosynthesis of crocacin involves an unusual hydrolytic release domain showing similarity to condensation domains.","URL":null,"raw_pages":"855-65","medline_journal":"Chem Biol","ISO_journal":"Chem Biol","authors":["Muller S","Rachid S","Hoffmann T","Surup F","Volz C","Zaburannyi N","Muller R."],"DOI_URL":null}},"set_info":{"accession":"CL0936","name":"PIM7_Imm50"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":26,"pathways":0,"proteins":26,"proteomes":26,"sets":1,"structural_models":{"alphafold":15},"structures":0,"taxa":105},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":13},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}