{"metadata":{"accession":"PF19764","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046218","hierarchy":null,"name":{"name":"Family of unknown function (DUF6251)","short":"DUF6251"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis [[cite:PUB00098957]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098957":{"PMID":19362651,"ISBN":null,"volume":"459","issue":null,"year":2009,"title":"Enzymology of aminoglycoside biosynthesis-deduction from gene clusters.","URL":null,"raw_pages":"459-91","medline_journal":"Methods Enzymol","ISO_journal":"Methods Enzymol","authors":["Wehmeier UF","Piepersberg W."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":107,"pathways":0,"proteins":107,"proteomes":89,"sets":0,"structural_models":{"alphafold":44},"structures":0,"taxa":119},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":48},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}