{"metadata":{"accession":"PF19760","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046214","hierarchy":null,"name":{"name":"Family of unknown function (DUF6247)","short":"DUF6247"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000345) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the eponemycin biosynthetic  gene cluster from Streptomyces hygroscopicus [[cite:PUB00099457],[cite:PUB00099416]]. This family appears to be predominantly found in Actinobacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099457":{"PMID":24168704,"ISBN":null,"volume":"9","issue":"1","year":2014,"title":"Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.","URL":null,"raw_pages":"301-9","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["Schorn M","Zettler J","Noel JP","Dorrestein PC","Moore BS","Kaysser L."],"DOI_URL":null},"PUB00099416":{"PMID":2106503,"ISBN":null,"volume":"43","issue":"1","year":1990,"title":"Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.","URL":null,"raw_pages":"8-18","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Sugawara K","Hatori M","Nishiyama Y","Tomita K","Kamei H","Konishi M","Oki T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1096,"pathways":0,"proteins":1088,"proteomes":670,"sets":0,"structural_models":{"alphafold":541},"structures":0,"taxa":841},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":493},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}