This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000267) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide. This entry includes a member from the saquayamycin Z biosynthetic gene cluster from Micromonospora sp. Tu 6368 [[cite:PUB00099446]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099446":{"PMID":19384899,"ISBN":null,"volume":"10","issue":"8","year":2009,"title":"Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains.","URL":null,"raw_pages":"1392-401","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Erb A","Luzhetskyy A","Hardter U","Bechthold A."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":205,"pathways":0,"proteins":205,"proteomes":112,"sets":0,"structural_models":{"alphafold":121},"structures":0,"taxa":129},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":81},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}