{"metadata":{"accession":"PF19752","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046206","hierarchy":null,"name":{"name":"Family of unknown function (DUF6239)","short":"DUF6239"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000081) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the kedarcidin biosynthetic gene cluster from Streptoalloteichus  sp. ATCC 53650 [[cite:PUB00098878],[cite:PUB00099428]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099428":{"PMID":23633564,"ISBN":null,"volume":"110","issue":"20","year":2013,"title":"A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway.","URL":null,"raw_pages":"8069-74","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Huang SX","Lohman JR","Huang T","Shen B."],"DOI_URL":null},"PUB00098878":{"PMID":23360970,"ISBN":null,"volume":"9","issue":"3","year":2013,"title":"Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.","URL":null,"raw_pages":"478-91","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Lohman JR","Huang SX","Horsman GP","Dilfer PE","Huang T","Chen Y","Wendt-Pienkowski E","Shen B."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":61,"pathways":0,"proteins":61,"proteomes":57,"sets":0,"structural_models":{"alphafold":35},"structures":0,"taxa":89},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}