This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001214) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the marformycin A biosynthetic gene cluster from Streptomyces drozdowiczii [[cite:PUB00099469]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099469":{"PMID":25746634,"ISBN":null,"volume":"17","issue":"6","year":2015,"title":"Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries.","URL":null,"raw_pages":"1509-12","medline_journal":"Org Lett","ISO_journal":"Org Lett","authors":["Liu J","Wang B","Li H","Xie Y","Li Q","Qin X","Zhang X","Ju J."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":19,"pathways":0,"proteins":19,"proteomes":18,"sets":0,"structural_models":{"alphafold":5},"structures":0,"taxa":35},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":10},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}