This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001973) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the fervenulin biosynthetic gene cluster from Streptomyces hiroshimensis [[cite:PUB00099459]]. This family appears to be predominantly found in Actinoabacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099459":{"PMID":30565634,"ISBN":null,"volume":"17","issue":"3","year":2019,"title":"Characterization of the N-methyltransferases involved in the biosynthesis of toxoflavin, fervenulin and reumycin from Streptomyces hiroshimensis ATCC53615.","URL":null,"raw_pages":"477-481","medline_journal":"Org Biomol Chem","ISO_journal":"Org Biomol Chem","authors":["Su C","Yan Y","Guo X","Luo J","Liu C","Zhang Z","Xiang WS","Huang SX."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":843,"pathways":0,"proteins":842,"proteomes":450,"sets":0,"structural_models":{"alphafold":304},"structures":0,"taxa":510},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":85,"alignment:full":339},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}