{"metadata":{"accession":"PF19742","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046199","hierarchy":null,"name":{"name":"Family of unknown function (DUF6231)","short":"DUF6231"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000387) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the mangotoxin biosynthetic gene cluster from Pseudomonas syringae pv. syringae [[cite:PUB00099371],[cite:PUB00099470]]. This family appears to be predominantly found in Proteobacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00099470":{"PMID":22615797,"ISBN":null,"volume":"7","issue":"5","year":2012,"title":"The mbo operon is specific and essential for biosynthesis of mangotoxin in Pseudomonas syringae.","URL":null,"raw_pages":"e36709","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Carrion VJ","Arrebola E","Cazorla FM","Murillo J","de Vicente A."],"DOI_URL":null},"PUB00099371":{"PMID":17506328,"ISBN":null,"volume":"20","issue":"5","year":2007,"title":"A nonribosomal peptide synthetase gene (mgoA) of Pseudomonas syringae pv. syringae is involved in mangotoxin biosynthesis and is required for full virulence.","URL":null,"raw_pages":"500-9","medline_journal":"Mol Plant Microbe Interact","ISO_journal":"Mol Plant Microbe Interact","authors":["Arrebola E","Cazorla FM","Romero D","Perez-Garcia A","de Vicente A."],"DOI_URL":null}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":682,"pathways":0,"proteins":682,"proteomes":680,"sets":1,"structural_models":{"alphafold":405},"structures":0,"taxa":866},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":175},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}