This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001774) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the MS-271 biosynthetic gene cluster from Streptomyces sp [[cite:PUB00099453]]. This family appears to be predominantly found in Actinobacteria. Some members of this family have been identified as putative cholesterol esterases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099453":{"PMID":29974638,"ISBN":null,"volume":"19","issue":"19","year":2018,"title":"Biosynthetic Gene Cluster of a d-Tryptophan-Containing Lasso Peptide, MS-271.","URL":null,"raw_pages":"2045-2048","medline_journal":"Chembiochem","ISO_journal":"Chembiochem","authors":["Feng Z","Ogasawara Y","Nomura S","Dairi T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":2566,"pathways":0,"proteins":2566,"proteomes":1589,"sets":0,"structural_models":{"alphafold":1332},"structures":0,"taxa":1916},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":183,"alignment:full":1245},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}