This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000118) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the pactamycin biosynthetic gene cluster from Streptomyces pactum [[cite:PUB00099419]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099419":{"PMID":17827660,"ISBN":null,"volume":"60","issue":"8","year":2007,"title":"Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.","URL":null,"raw_pages":"492-503","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Kudo F","Kasama Y","Hirayama T","Eguchi T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":702,"pathways":0,"proteins":699,"proteomes":693,"sets":0,"structural_models":{"alphafold":292},"structures":0,"taxa":738},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":340},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}