This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000223) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the rabelomycin biosynthetic gene cluster from uncultured bacterium BAC AB649/1850 [[cite:PUB00098876]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098876":{"PMID":20690632,"ISBN":null,"volume":"132","issue":"34","year":2010,"title":"Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster.","URL":null,"raw_pages":"11902-3","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Feng Z","Kim JH","Brady SF."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":389,"pathways":0,"proteins":387,"proteomes":376,"sets":0,"structural_models":{"alphafold":219},"structures":0,"taxa":577},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":204},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}