This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000896) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the cycloserine biosynthetic gene cluster from Streptomyces lavendulae subsp. lavendulae [[cite:PUB00098976]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098976":{"PMID":20086163,"ISBN":null,"volume":"54","issue":"3","year":2010,"title":"Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.","URL":null,"raw_pages":"1132-9","medline_journal":"Antimicrob Agents Chemother","ISO_journal":"Antimicrob Agents Chemother","authors":["Kumagai T","Koyama Y","Oda K","Noda M","Matoba Y","Sugiyama M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":92,"pathways":0,"proteins":91,"proteomes":80,"sets":0,"structural_models":{"alphafold":39},"structures":0,"taxa":153},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":27,"alignment:full":54},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}