This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001848) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the diazaquinomycin H biosynthetic gene cluster from Micromonospora sp. B006 [[cite:PUB00098974]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098974":{"PMID":30896942,"ISBN":null,"volume":"82","issue":"4","year":2019,"title":"Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.","URL":null,"raw_pages":"937-946","medline_journal":"J Nat Prod","ISO_journal":"J Nat Prod","authors":["Braesel J","Lee JH","Arnould B","Murphy BT","Eustaquio AS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":811,"pathways":0,"proteins":810,"proteomes":738,"sets":0,"structural_models":{"alphafold":402},"structures":0,"taxa":959},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":91,"alignment:full":320},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}