This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001065) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the herboxidiene biosynthetic gene cluster from Streptomyces chromofuscus [[cite:PUB00098901]]. This family appears to be predominantly found in Actinobacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098901":{"PMID":22247174,"ISBN":null,"volume":"78","issue":"6","year":2012,"title":"Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.","URL":null,"raw_pages":"2034-8","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Shao L","Zi J","Zeng J","Zhan J."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":1066,"pathways":0,"proteins":1065,"proteomes":777,"sets":0,"structural_models":{"alphafold":552},"structures":0,"taxa":1042},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":554},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}