This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001612) is described by MIBiG as an example of the following biosynthetic class, alkaloid. It includes a member from the ambiguine H isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903 [[cite:PUB00099402]]. This family appears to be predominantly found in bacteria.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099402":{"PMID":26629885,"ISBN":null,"volume":"137","issue":"49","year":2015,"title":"Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.","URL":null,"raw_pages":"15366-9","medline_journal":"J Am Chem Soc","ISO_journal":"J Am Chem Soc","authors":["Li S","Lowell AN","Yu F","Raveh A","Newmister SA","Bair N","Schaub JM","Williams RM","Sherman DH."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":651,"pathways":0,"proteins":651,"proteomes":546,"sets":0,"structural_models":{"alphafold":392},"structures":0,"taxa":988},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":106,"alignment:full":328},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}